1,177 research outputs found
Spatio-Temporal Fusion Networks for Action Recognition
The video based CNN works have focused on effective ways to fuse appearance
and motion networks, but they typically lack utilizing temporal information
over video frames. In this work, we present a novel spatio-temporal fusion
network (STFN) that integrates temporal dynamics of appearance and motion
information from entire videos. The captured temporal dynamic information is
then aggregated for a better video level representation and learned via
end-to-end training. The spatio-temporal fusion network consists of two set of
Residual Inception blocks that extract temporal dynamics and a fusion
connection for appearance and motion features. The benefits of STFN are: (a) it
captures local and global temporal dynamics of complementary data to learn
video-wide information; and (b) it is applicable to any network for video
classification to boost performance. We explore a variety of design choices for
STFN and verify how the network performance is varied with the ablation
studies. We perform experiments on two challenging human activity datasets,
UCF101 and HMDB51, and achieve the state-of-the-art results with the best
network
The N-terminal intrinsically disordered domain of mgm101p is localized to the mitochondrial nucleoid.
The mitochondrial genome maintenance gene, MGM101, is essential for yeasts that depend on mitochondrial DNA replication. Previously, in Saccharomyces cerevisiae, it has been found that the carboxy-terminal two-thirds of Mgm101p has a functional core. Furthermore, there is a high level of amino acid sequence conservation in this region from widely diverse species. By contrast, the amino-terminal region, that is also essential for function, does not have recognizable conservation. Using a bioinformatic approach we find that the functional core from yeast and a corresponding region of Mgm101p from the coral Acropora millepora have an ordered structure, while the N-terminal domains of sequences from yeast and coral are predicted to be disordered. To examine whether ordered and disordered domains of Mgm101p have specific or general functions we made chimeric proteins from yeast and coral by swapping the two regions. We find, by an in vivo assay in S.cerevisiae, that the ordered domain of A.millepora can functionally replace the yeast core region but the disordered domain of the coral protein cannot substitute for its yeast counterpart. Mgm101p is found in the mitochondrial nucleoid along with enzymes and proteins involved in mtDNA replication. By attaching green fluorescent protein to the N-terminal disordered domain of yeast Mgm101p we find that GFP is still directed to the mitochondrial nucleoid where full-length Mgm101p-GFP is targeted
Microscopic Realization of the Kerr/CFT Correspondence
Supersymmetric M/string compactifications to five dimensions contain BPS
black string solutions with magnetic graviphoton charge P and near-horizon
geometries which are quotients of AdS_3 x S^2. The holographic duals are
typically known 2D CFTs with central charges c_L=c_R=6P^3 for large P. These
same 5D compactifications also contain non-BPS but extreme Kerr-Newman black
hole solutions with SU(2)_L spin J_L and electric graviphoton charge Q obeying
Q^3 \leq J_L^2. It is shown that in the maximally charged limit Q^3 -> J_L^2,
the near-horizon geometry coincides precisely with the right-moving temperature
T_R=0 limit of the black string with magnetic charge P=J_L^{1/3}. The known
dual of the latter is identified as the c_L=c_R=6J_L CFT predicted by the
Kerr/CFT correspondence. Moreover, at linear order away from maximality, one
finds a T_R \neq 0 quotient of the AdS_3 factor of the black string solution
and the associated thermal CFT entropy reproduces the linearly sub-maximal
Kerr-Newman entropy. Beyond linear order, for general Q^3<J_L^2, one has a
finite-temperature quotient of a warped deformation of the magnetic string
geometry. The corresponding dual deformation of the magnetic string CFT
potentially supplies, for the general case, the c_L=c_R=6J_L CFT predicted by
Kerr/CFT.Comment: 18 pages, no figure
Cardiac Transcription Factor Nkx2.5 Is Downregulated under Excessive O-GlcNAcylation Condition
Post-translational modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) is linked the development of diabetic cardiomyopathy. We investigated whether Nkx2.5 protein, a cardiac transcription factor, is regulated by O-GlcNAc. Recombinant Nkx2.5 (myc-Nkx2.5) proteins were reduced by treatment with the O-GlcNAcase inhibitors STZ and O-(2-acetamido-2-deoxy-D-glucopyroanosylidene)-amino-N-phenylcarbamate; PUGNAC) as well as the overexpression of recombinant O-GlcNAc transferase (OGT-flag). Co-immunoprecipitation analysis revealed that myc-Nkx2.5 and OGT-flag proteins interacted and myc-Nkx2.5 proteins were modified by O-GlcNAc. In addition, Nkx2.5 proteins were reduced in the heart tissue of streptozotocin (STZ)-induced diabetic mice and O-GlcNAc modification of Nkx2.5 protein increased in diabetic heart tissue compared with non-diabetic heart. Thus, excessive O-GlcNAcylation causes downregulation of Nkx2.5, which may be an underlying contributing factor for the development of diabetic cardiomyopathy
Minding impacting events in a model of stochastic variance
We introduce a generalisation of the well-known ARCH process, widely used for
generating uncorrelated stochastic time series with long-term non-Gaussian
distributions and long-lasting correlations in the (instantaneous) standard
deviation exhibiting a clustering profile. Specifically, inspired by the fact
that in a variety of systems impacting events are hardly forgot, we split the
process into two different regimes: a first one for regular periods where the
average volatility of the fluctuations within a certain period of time is below
a certain threshold and another one when the local standard deviation
outnumbers it. In the former situation we use standard rules for
heteroscedastic processes whereas in the latter case the system starts
recalling past values that surpassed the threshold. Our results show that for
appropriate parameter values the model is able to provide fat tailed
probability density functions and strong persistence of the instantaneous
variance characterised by large values of the Hurst exponent is greater than
0.8, which are ubiquitous features in complex systems.Comment: 18 pages, 5 figures, 1 table. To published in PLoS on
Concurrent use of prescription drugs and herbal medicinal products in older adults: A systematic review
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The use of herbal medicinal products (HMPs) is common among older adults. However, little is known about concurrent use with prescription drugs as well as the potential interactions associated with such combinations. Objective Identify and evaluate the literature on concurrent prescription and HMPs use among older adults to assess prevalence, patterns, potential interactions and factors associated with this use. Methods Systematic searches in MEDLINE, PsycINFO, EMBASE, CINAHL, AMED, Web of Science and Cochrane from inception to May 2017 for studies reporting concurrent use of prescription medicines with HMPs in adults (≥65 years). Quality was assessed using the Joanna Briggs Institute checklists. The Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre) three stage approach to mixed method research was used to synthesise data. Results Twenty-two studies were included. A definition of HMPs or what was considered HMP was frequently missing. Prevalence of concurrent use by older adults varied widely between 5.3% and 88.3%. Prescription medicines most combined with HMPs were antihypertensive drugs, beta blockers, diuretics, antihyperlipidemic agents, anticoagulants, analgesics, antihistamines, antidiabetics, antidepressants and statins. The HMPs most frequently used were: ginkgo, garlic, ginseng, St John’s wort, Echinacea, saw palmetto, evening primrose oil and ginger. Potential risks of bleeding due to use of ginkgo, garlic or ginseng with aspirin or warfarin was the most reported herb-drug interaction. Some data suggests being female, a lower household income and less than high school education were associated with concurrent use. Conclusion Prevalence of concurrent prescription drugs and HMPs use among older adults is substantial and potential interactions have been reported. Knowledge of the extent and manner in which older adults combine prescription drugs will aid healthcare professionals can appropriately identify and manage patients at risk.Peer reviewedFinal Published versio
Measurement of the Negative Muon Anomalous Magnetic Moment to 0.7 ppm
The anomalous magnetic moment of the negative muon has been measured to a
precision of 0.7 parts per million (ppm) at the Brookhaven Alternating Gradient
Synchrotron. This result is based on data collected in 2001, and is over an
order of magnitude more precise than the previous measurement of the negative
muon. The result a_mu= 11 659 214(8)(3) \times 10^{-10} (0.7 ppm), where the
first uncertainty is statistical and the second is sytematic, is consistend
with previous measurements of the anomaly for the positive and negative muon.
The average for the muon anomaly a_{mu}(exp) = 11 659 208(6) \times 10^{-10}
(0.5ppm).Comment: 4 pages, 4 figures, submitted to Physical Review Letters, revised to
reflect referee comments. Text further revised to reflect additional referee
comments and a corrected Fig. 3 replaces the older versio
Hydrodynamics of a 5D Einstein-dilaton black hole solution and the corresponding BPS state
We apply the potential reconstruction approach to generate a series of
asymptotically AdS (aAdS) black hole solutions, with a self-interacting bulk
scalar field. Based on the method, we reproduce the pure AdS solution as a
consistency check and we also generate a simple analytic 5D black hole
solution. We then study various aspects of this solution, such as temperature,
entropy density and conserved charges. Furthermore, we study the hydrodynamics
of this black hole solution in the framework of fluid/gravity duality, e.g. the
ratio of the shear viscosity to the entropy density. In a degenerate case of
the 5D black hole solution, we find that the c function decreases monotonically
from UV to IR as expected. Finally, we investigate the stability of the
degenerate solution by studying the bosonic functional energy of the gravity
and the Witten-Nester energy . We confirm that the degenerate solution
is a BPS domain wall solution. The corresponding superpotential and the
solution of the killing spinor equation are found explicitly.Comment: V2: 23 pages, no figure, minor changes, typos corrected, new
references and comments added, version accepted by JHE
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